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Symptoms of Schizophrenia

Schizophrenia symptoms are typically separated into 2 categories:

Positive symptoms: Feelings or behaviors that are usually not present,
such as:

  • Believing that what other people are saying is not true (delusions)
  • Hearing, seeing, tasting, feeling, or smelling things that others do not experience (hallucinations)
  • Disorganized speech and behavior

Approved for the treatment of schizophrenia and schizoaffective disorder.Please discuss your symptoms with your healthcare professional. He or she will review your symptoms and may consult the established guidelines, which are available in the Diagnostic and Statistical Manual of Mental Disorders, where applicable.

Negative symptoms: A lack of feelings or behaviors that are usually present,
such as:

  • Losing interest in everyday activities, like bathing, grooming, or getting dressed
  • Feeling out of touch with other people, family, or friends
  • Lack of feeling or emotion (apathy)
  • Having little emotion or inappropriate feelings in certain situations
  • Having less ability to experience pleasure

Approved for the treatment of schizophrenia and schizoaffective disorder.Please discuss your symptoms with your healthcare professional. He or she will review your symptoms and may consult the established guidelines, which are available in the Diagnostic and Statistical Manual of Mental Disorders, where applicable.

Schizophrenia affects people differently and symptoms can vary from person to person. Some people may have many symptoms, while others may only have a few.

Men diagnosed with schizophrenia usually start to show symptoms between their late teens and early 20s. Women usually develop symptoms during their mid-20s to early 30s.

There are things you can do to help manage your symptoms. Work with your doctor and Treatment Team to learn more about the schizophrenia symptoms you might experience and develop a treatment plan that works for you.

IMPORTANT SAFETY INFORMATION and INDICATION

INVEGA SUSTENNA® (paliperidone palmitate) is indicated for schizophrenia and schizoaffective disorder.

INVEGA SUSTENNA® can cause serious side effects, including an increased risk of death in elderly people who are confused, have memory loss, and have lost touch with reality (dementia-related psychosis). INVEGA SUSTENNA® is not approved for treating dementia-related psychosis.

Do not receive INVEGA SUSTENNA® if you are allergic to paliperidone, risperidone, or any of the ingredients in INVEGA SUSTENNA®. See end of the Patient Information leaflet in the full Prescribing Information for a complete list of INVEGA SUSTENNA® ingredients.

Before you receive INVEGA SUSTENNA®, tell your healthcare provider about all your medical conditions, including if you:

  • have had Neuroleptic Malignant Syndrome (NMS)
  • have or have had heart problems, including a heart attack, heart failure, abnormal heart rhythm, or long QT syndrome
  • have or have had low levels of potassium or magnesium in your blood
  • have or have had uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia)
  • have or have had kidney or liver problems
  • have diabetes or have a family history of diabetes
  • have had a low white blood cell count
  • have had problems with dizziness or fainting or are being treated for high blood pressure
  • have or have had seizures or epilepsy
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if INVEGA SUSTENNA® will harm your unborn baby
  • are breastfeeding or plan to breastfeed. INVEGA SUSTENNA® can pass into your breast milk and may harm your baby. You and your healthcare provider should decide if you will receive INVEGA SUSTENNA® or breastfeed. You should not do both

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show to your healthcare provider or pharmacist when you get a new medicine.

What should I avoid while receiving INVEGA SUSTENNA®?

  • INVEGA SUSTENNA® may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how INVEGA SUSTENNA® affects you
  • avoid getting overheated or dehydrated

INVEGA SUSTENNA® may cause serious side effects, including:

  • stroke in elderly people (cerebrovascular problems) that can lead to death
  • Neuroleptic Malignant Syndrome (NMS). NMS is a rare but very serious problem that can happen in people who receive INVEGA SUSTENNA®. NMS can cause death and must be treated in a hospital. Call your healthcare provider right away if you become severely ill and have any of these symptoms: high fever; severe muscle stiffness; confusion; loss of consciousness; changes in your breathing, heartbeat, and blood pressure
  • problems with your heartbeat. Heart problems can cause death. Call your healthcare provider right away if you have any of these symptoms: passing out or feeling like you will pass out; dizziness; or feeling as if your heart is pounding or missing beats
  • uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia)
  • metabolic changes. Metabolic changes may include high blood sugar (hyperglycemia), diabetes mellitus and changes in the fat levels in your blood (dyslipidemia), and weight gain
  • low blood pressure and fainting
  • changes in your blood cell counts
  • high level of prolactin in your blood (hyperprolactinemia). INVEGA SUSTENNA® may cause a rise in the blood levels of a hormone called prolactin (hyperprolactinemia) that may cause side effects including missed menstrual periods, leakage of milk from the breasts, development of breasts in men, or problems with erection
  • problems thinking clearly and moving your body
  • seizures
  • difficulty swallowing that can cause food or liquid to get into your lungs
  • prolonged or painful erection lasting more than 4 hours. Call your healthcare provider or go to your nearest emergency room right away if you have an erection that lasts more than 4 hours
  • problems with control of your body temperature, especially when you exercise a lot or spend time doing things that make you warm. It is important for you to drink water to avoid dehydration
  • Call your doctor right away if you start thinking about suicide or wanting to hurt yourself

The most common side effects of INVEGA SUSTENNA® include: injection site reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or needing to be constantly moving; abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of INVEGA SUSTENNA®. For more information, ask your healthcare provider or pharmacist.

Please see full Prescribing Information, including Boxed Warning

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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