Symptoms of Schizophrenia

Schizophrenia symptoms are typically separated into 2 categories:

Positive symptoms: Feelings or behaviors that are usually not present,
such as:

  • Believing that what other people are saying is not true (delusions)
  • Hearing, seeing, tasting, feeling, or smelling things that others do not experience (hallucinations)
  • Disorganized speech and behavior

Approved for the treatment of schizophrenia and schizoaffective disorder.Please discuss your symptoms with your healthcare professional. He or she will review your symptoms and may consult the established guidelines, which are available in the Diagnostic and Statistical Manual of Mental Disorders, where applicable.

Negative symptoms: A lack of feelings or behaviors that are usually present,
such as:

  • Losing interest in everyday activities, like bathing, grooming, or getting dressed
  • Feeling out of touch with other people, family, or friends
  • Lack of feeling or emotion (apathy)
  • Having little emotion or inappropriate feelings in certain situations
  • Having less ability to experience pleasure

Approved for the treatment of schizophrenia and schizoaffective disorder.Please discuss your symptoms with your healthcare professional. He or she will review your symptoms and may consult the established guidelines, which are available in the Diagnostic and Statistical Manual of Mental Disorders, where applicable.

Schizophrenia affects people differently and symptoms can vary from person to person. Some people may have many symptoms, while others may only have a few.

Men diagnosed with schizophrenia usually start to show symptoms between their late teens and early 20s. Women usually develop symptoms during their mid-20s to early 30s.

There are things you can do to help manage your symptoms. Work with your doctor and Treatment Team to learn more about the schizophrenia symptoms you might experience and develop a treatment plan that works for you.

  • Psychiatrist

    Your relationship with your psychiatrist is one of the most important parts of the treatment process. Your psychiatrist:
    • Diagnoses and treats mental health conditions, like schizophrenia
    • May prescribe your medication
    • Is the doctor you should call first if you have questions about your treatment plan
    • If you think you may be experiencing side effects or symptoms, contact either your psychiatrist or primary care physician


    Keep a list of any questions you think of between appointments and take it with you to your next appointment.

  • Primary Care Physician

    Primary Care Physician
    This is the doctor who monitors your overall physical health. Your primary care physician:
    • Checks your general health and wellness
    • Treats any general health conditions (like the flu)
    • May refer you to specialists for certain health conditions
    • If you think you may be experiencing side effects or symptoms, contact either your psychiatrist or primary care physician


    Talk to this doctor about any health goals like losing weight or starting an exercise program. He or she can help you figure out which steps to take next.

  • Nurse

    Your nurse provides you with care and treatment that supports your doctor’s diagnosis and instruction. Your nurse may:
    • Give your medication
    • Check for side effects
    • Learn about your progress


    Feel free to ask your nurse any questions you may have about your medication, your injections, or potential side effects.

  • Nurse

    Nurse @br@Practitioner
    A nurse practitioner gives you care and treatment that supports your psychiatrist’s diagnosis and instructions. Some psychiatric nurse practitioners can also:
    • Assess your condition
    • Prescribe and administer medication
    • Monitor for side effects


    Have questions for your doctor? Go ahead and ask your nurse practitioner if you see him or her first. Your nurse practitioner will share information with your doctor.

  • Case Manager

    Case Manager
    Case managers are responsible for coordinating medical and mental health care, as well as any necessary support services. Your case manager can help make sure:
    • You have access to ongoing medical care
    • You have access to services like job training, benefits programs, or housing


    Looking for a new place to live? Your case manager can help you find a housing program—and any other resources you may need.

  • Psychologist

    A psychologist is a professional who can:
    • Help you work through emotional or behavioral issues
    • Provide therapy—both one-on-one or in a group
    • Help family members better understand you and your condition through family therapy


    Living with schizophrenia can be challenging. Your psychologist is there to help you work through how you’re feeling, so open up and share.

  • Peer Counselor

    Peer Counselor
    Peer counselors are people who are also living with serious mental health conditions. They can:
    • Share their experiences living with a mental health condition
    • Tell you about resources that have been useful to them
    • Listen to what you’re going through and relate in a way other people may not be able to


    Don’t be shy about sharing with your peer counselor. Chances are, he or she may have been through something similar.

  • Pharmacist

    Your pharmacist knows all about the different medications you may be taking. He or she can:
    • Help you understand why you are taking your medications, your dosages, and potential side effects
    • Along with your doctor can help you understand what you should or shouldn't do on certain medications
    • Possibly administer your injection, depending on where you live and your doctor’s instruction


    Have a question about your medications and how you should be doing when you take them? Ask your pharmacist!

  • Family & Friends

    Family & Friends
    Trusted family, friends, mentors, or religious personnel can help provide you with support and social interaction during the treatment process. Turn to them when:
    • You’re feeling isolated or need someone to talk to
    • You need to spend time with people who know and care about you
    • You want to plan an activity—like taking a walk, making dinner, or going to a movie


    Open communication can help your family and friends understand what you’re going through. Tell them what you need in terms of help or support—otherwise they might not really know.

  • Understanding
    Your Condition

    The more you know about schizophrenia, the more actively you’ll be able to participate in your treatment. Gaining deeper insight into your condition can help you better understand your medication and recognize symptoms or signs of relapse—so you’ll know when to talk to your doctor and seek help.

    Learning about the challenges of—and treatments for—a lifelong mental health condition can also help you stay committed to the recovery process. As you get deeper into the recovery process, you may find it helpful to share your experiences, either in a group setting or by becoming a peer counselor. Other people living with schizophrenia may really benefit from what you have to say.

  • Staying on

    Medication is a key part of the mental health recovery process.
    It’s important that you take all of your medications, including INVEGA® SUSTENNA® (paliperdone palmitate), exactly as directed by your doctor—even if you’re feeling better. Stopping your medication may cause your symptoms to return.

    You should also review all of your medications with your doctor or pharmacist on a regular basis. That way you can stay informed on how each medication works, and make sure all your medications work together.

  • Setting Goals

    Setting goals can help you succeed at things that are important to you. Writing down your goals and breaking them down into manageable steps can also help you make progress. Consider both short- and long-term goals, and try to work to reach them.

    • Short-term goals might be:
      • Taking medication as prescribed by your doctor
      • Keeping up with your laundry
      • Learning to cook something new
    • Long-term goals might be:
      • Finding a job
      • Taking a class
      • Sticking to a long-term exercise plan
  • Looking After Your
    Total Health

    Along with taking all of your medications as directed, there are other things you can do to improve your total health. Make sure you get a physical examination at least once a year. Talk to your doctor about a sensible eating and exercise plan. And ask your Treatment Team for help with quitting unhealthy habits like smoking, drinking alcohol, or other substance abuse. Establishing a daily routine can help you stay on track with your healthier lifestyle—and your overall treatment plan.

  • Getting Additional
    Therapy & Treatment

    Beyond your regular doctor and injection appointments, there may be other resources that can help support your recovery process. Some of these resources may include:

    • Individual psychotherapy sessions
    • Family-focused therapy
    • Group therapy sessions
    • Local community support programs
    • Drug and alcohol treatment

    To access local resources, talk to your Treatment Team and check out these websites:

  • Getting the Support
    You Need

    There are times you’ll need support in the mental health recovery process, and it’s good to know that you’re not alone. The members of your Treatment Team will be there for you, so don’t be afraid to ask for help. There are also resources in your community and online that you can access when you need them.

  • Relapse Recognition
    & Management

    Learning to recognize the early signs of relapse—and alerting your doctor immediately—can be a very important part of participating in your treatment plan. Because symptoms of schizophrenia can be triggered by events from everyday life, there is a chance that a relapse may occur—even when a person is taking his or her medicine correctly.

    Remember, only your doctor can decide what course of treatment is right for you. For a list of early warning signs, click here.



INVEGA® SUSTENNA® (paliperidone palmitate) is indicated for schizophrenia and schizoaffective disorder.

INVEGA® SUSTENNA® can cause serious side effects, including an increased risk of death in elderly people who are confused, have memory loss, and have lost touch with reality (dementia-related psychosis). INVEGA® SUSTENNA® is not approved for treating dementia-related psychosis.

Do not receive INVEGA® SUSTENNA® if you are allergic to paliperidone, risperidone, or any of the ingredients in INVEGA® SUSTENNA®. See end of the Patient Information leaflet in the full Prescribing Information for a complete list of INVEGA® SUSTENNA® ingredients.

Before you receive INVEGA® SUSTENNA®, tell your healthcare provider about all your medical conditions, including if you:

  • have had Neuroleptic Malignant Syndrome (NMS)
  • have or have had heart problems, including a heart attack, heart failure, abnormal heart rhythm, or long QT syndrome
  • have or have had low levels of potassium or magnesium in your blood
  • have or have had uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia)
  • have or have had kidney or liver problems
  • have diabetes or have a family history of diabetes
  • have had a low white blood cell count
  • have had problems with dizziness or fainting or are being treated for high blood pressure
  • have or have had seizures or epilepsy
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if INVEGA® SUSTENNA® will harm your unborn baby
  • are breastfeeding or plan to breastfeed. INVEGA® SUSTENNA® can pass into your breast milk and may harm your baby. You and your healthcare provider should decide if you will receive INVEGA® SUSTENNA® or breastfeed. You should not do both

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show to your healthcare provider or pharmacist when you get a new medicine.

What should I avoid while receiving INVEGA® SUSTENNA®?

  • INVEGA® SUSTENNA® may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how INVEGA® SUSTENNA® affects you
  • avoid getting overheated or dehydrated

INVEGA® SUSTENNA® may cause serious side effects, including:

  • stroke in elderly people (cerebrovascular problems) that can lead to death
  • Neuroleptic Malignant Syndrome (NMS). NMS is a rare but very serious problem that can happen in people who receive INVEGA® SUSTENNA®. NMS can cause death and must be treated in a hospital. Call your healthcare provider right away if you become severely ill and have any of these symptoms: high fever; severe muscle stiffness; confusion; loss of consciousness; changes in your breathing, heartbeat, and blood pressure
  • problems with your heartbeat. Heart problems can cause death. Call your healthcare provider right away if you have any of these symptoms: passing out or feeling like you will pass out; dizziness; or feeling as if your heart is pounding or missing beats
  • uncontrolled movements of your tongue, face, mouth, or jaw (tardive dyskinesia)
  • metabolic changes. Metabolic changes may include high blood sugar (hyperglycemia), diabetes mellitus and changes in the fat levels in your blood (dyslipidemia), and weight gain
  • low blood pressure and fainting
  • changes in your blood cell counts
  • high level of prolactin in your blood (hyperprolactinemia). INVEGA® SUSTENNA® may cause a rise in the blood levels of a hormone called prolactin (hyperprolactinemia) that may cause side effects including missed menstrual periods, leakage of milk from the breasts, development of breasts in men, or problems with erection
  • problems thinking clearly and moving your body
  • seizures
  • difficulty swallowing that can cause food or liquid to get into your lungs
  • prolonged or painful erection lasting more than 4 hours. Call your healthcare provider or go to your nearest emergency room right away if you have an erection that lasts more than 4 hours
  • problems with control of your body temperature, especially when you exercise a lot or spend time doing things that make you warm. It is important for you to drink water to avoid dehydration
  • Call your doctor right away if you start thinking about suicide or wanting to hurt yourself

The most common side effects of INVEGA® SUSTENNA® include: injection site reactions; sleepiness or drowsiness; dizziness; feeling of inner restlessness or needing to be constantly moving; abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your eyes.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of INVEGA® SUSTENNA®. For more information, ask your healthcare provider or pharmacist.

Please see full Prescribing Information, including Boxed Warning

You are encouraged to report side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.